Analysis of epistasis in linked regions in the Irish study of high‐density schizophrenia families
Identifieur interne : 009385 ( Main/Exploration ); précédent : 009384; suivant : 009386Analysis of epistasis in linked regions in the Irish study of high‐density schizophrenia families
Auteurs : Patrick F. Sullivan [États-Unis] ; F. Anthony O'Neill [États-Unis] ; Dermot Walsh [États-Unis] ; Yunlong Ma [États-Unis] ; Kenneth S. Kendler [États-Unis] ; Richard E. Straub [États-Unis]Source :
- American Journal of Medical Genetics [ 0148-7299 ] ; 2001-04-08.
English descriptors
- Teeft :
- Behavioral genetics, Chromosomal regions, Chromosome, Complex traits, Diabetes mellitus, Entire sample, Epistasis, Epistatic, Epistatic interaction, Epistatic interactions, Genet, Genet straub, Genetic linkage, Genome, Genome scan, Genome scan strategy, Genomic regions, Genotyped individuals, Grant sponsor, Illness chromosome, Initial phase, Intermediate category, Irish study, Ishdsf, Ishdsf family, Kendler, Linkage, Linkage results, Linkage signal, Locus, Medical records, Multiplex pedigrees, Narrow category, Northern ireland, Pairwise comparisons, Pearson correlation, Psychiatry kendler, Psychiatry straub, Roscommon, Roscommon family study, Schizoaffective disorder, Schizophr bull kendler, Schizophrenia, Schizophrenia families, Simple schizophrenia, Statistical approach, Straub, Support interval, Virginia commonwealth university.
Abstract
Epistasis may be important in the etiology of schizophrenia. Analysis of epistasis has been important in the positional cloning of a gene involved in the etiology of type II diabetes mellitus. We investigated the importance of epistasis among six linked regions in 268 multiplex pedigrees in the Irish Study of High‐Density Schizophrenia Families (ISHDSF) by computing pairwise correlations between nonparametric linkage scores for narrow, intermediate, and broad diagnostic definitions. The linked regions were on chromosomes 2, 4, 5, 6, 8, and 10. No correlation reached our a priori level of statistical significance. Using this statistical approach, we did not find evidence of important epistatic effects among these six regions in the ISHDSF. © 2001 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajmg.1324
Affiliations:
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Analysis of epistasis has been important in the positional cloning of a gene involved in the etiology of type II diabetes mellitus. We investigated the importance of epistasis among six linked regions in 268 multiplex pedigrees in the Irish Study of High‐Density Schizophrenia Families (ISHDSF) by computing pairwise correlations between nonparametric linkage scores for narrow, intermediate, and broad diagnostic definitions. The linked regions were on chromosomes 2, 4, 5, 6, 8, and 10. No correlation reached our a priori level of statistical significance. Using this statistical approach, we did not find evidence of important epistatic effects among these six regions in the ISHDSF. © 2001 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Virginie</li></region></list><tree><country name="États-Unis"><region name="Virginie"><name sortKey="Sullivan, Patrick F" sort="Sullivan, Patrick F" uniqKey="Sullivan P" first="Patrick F." last="Sullivan">Patrick F. Sullivan</name></region><name sortKey="Kendler, Kenneth S" sort="Kendler, Kenneth S" uniqKey="Kendler K" first="Kenneth S." last="Kendler">Kenneth S. Kendler</name><name sortKey="Ma, Yunlong" sort="Ma, Yunlong" uniqKey="Ma Y" first="Yunlong" last="Ma">Yunlong Ma</name><name sortKey="O Neill, F Anthony" sort="O Neill, F Anthony" uniqKey="O Neill F" first="F. Anthony" last="O'Neill">F. Anthony O'Neill</name><name sortKey="Straub, Richard E" sort="Straub, Richard E" uniqKey="Straub R" first="Richard E." last="Straub">Richard E. Straub</name><name sortKey="Sullivan, Patrick F" sort="Sullivan, Patrick F" uniqKey="Sullivan P" first="Patrick F." last="Sullivan">Patrick F. Sullivan</name><name sortKey="Sullivan, Patrick F" sort="Sullivan, Patrick F" uniqKey="Sullivan P" first="Patrick F." last="Sullivan">Patrick F. Sullivan</name><name sortKey="Walsh, Dermot" sort="Walsh, Dermot" uniqKey="Walsh D" first="Dermot" last="Walsh">Dermot Walsh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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